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A lipoxygenase inhibitor from Aspergillus niger

Sekhar Rao, K.C. and Divakar, S. and Appu Rao, A. G. and Karanth, N.G. (2002) A lipoxygenase inhibitor from Aspergillus niger. Applied Microbiology and Biotechnology, 58. pp. 539-542.

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Abstract

<p align="justify">A lipoxygenase-1 (LOX-1) inhibitor was isolated from the fermented broth of Aspergillus niger CFTRI 1105. It was purified, using column and preparative thin layer chromatography. 1H NMR and GC-MS examination revealed the structure of the inhibitor to be 2-(22-methyl, 42-hydroxyphenyl), 2-(422hydroxyphenyl)-propane with a molecular weight of 242 and the molecular formula C16H18O2. This bisphenol-derivative inhibitor shows 50% inhibition of soybean LOX-1 at 0.98 mM concentration. The activity of this inhibitor was compared with commercial bisphenol A and its structural analogues,butylhydroxyanisole and butylhydroxytoluene in an attempt to understand the role of functional groups affecting lipoxygenase activity.</p>

Item Type: Article
Uncontrolled Keywords: lipoxygenase inhibitor aspergillus niger
Subjects: 600 Technology > 05 Chemical engineering > 04 Fermentation Technology
500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 04 Fungi
Divisions: Fermentation Technology and Bioengineering
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 21 Nov 2005
Last Modified: 28 Dec 2011 09:25
URI: http://ir.cftri.com/id/eprint/220

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