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Field-assisted extraction of cells, particles and macromolecules.

Raghavarao, K. S. M. S. and Doddamane, Srinivas N and Sampangi, Chethana and Todd, Paul W (2002) Field-assisted extraction of cells, particles and macromolecules. Trends in Biotechnology, 20 (2). pp. 72-78. ISSN 0167-7799

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Improved bioseparation techniques are increasingly important for biotechnology because separation is often the limiting factor for the success of biological processes. Manufacturers of new enzymes and pharmaceutical products require improved methods for recovering intact cells and intracellular products. Similarly the isolation, purification and concentration of many biomolecules produced in fermentation processes is extremely important. Often such downstream processing contributes a large portion of the product cost and thus efficient and economical alternative approaches to bioseparation processes are needed to eliminate, reduce or facilitate the handling of solids. Field-assisted separations, which hold immense potential for providing a major improvement in bioseparation in the near future, are considered in this review. Special emphasis is given to multistage methods, which are cost-effective compared with competing technologies. Commercial applications of these methods are detailed, we present suggestions for future work and we analyse the scale-up and economic aspects of these processes.

Item Type: Article
Uncontrolled Keywords: Bioseparation; Fermentation; Biomolecules; Downstream processing
Subjects: 600 Technology > 08 Food technology > 07 Food Engineering
Divisions: Food Engineering
Depositing User: Somashekar K.S
Date Deposited: 21 Jun 2011 09:43
Last Modified: 10 Oct 2018 10:48
URI: http://ir.cftri.com/id/eprint/2120

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