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A lipoxygenase inhibitor from Aspergillus niger.

Sekhar Rao, K. C. and Divakar, S. and Appu Rao, A. G. and Karanth, N. G. and Sattur, A. P. (2002) A lipoxygenase inhibitor from Aspergillus niger. Applied Microbiology and Biotechnology, 58 (4). pp. 539-42. ISSN 0175-7598

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A lipoxygenase-1 (LOX-1) inhibitor was isolated from the fermented broth of Aspergillus niger CFTRI 1105. It was purified, using column and preparative thin layer chromatography. 1H NMR and GC-MS examination revealed the structure of the inhibitor to be 2-(2'-methyl, 4'-hydroxyphenyl), 2-(4"hydroxyphenyl)-propane with a molecular weight of 242 and the molecular formula C,6H18O2. This bisphenol-derivative inhibitor shows 50% inhibition of soybean LOX-I at 0.98 mM concentration. The activity of this inhibitor was compared with commercial bisphenol A and its structural analogues, butylhydroxyanisole and butylhydroxytoluene in an attempt to understand the role of functional groups affecting lipoxygenase activity.

Item Type: Article
Uncontrolled Keywords: Lipoxygenases, Aspergillus niger, LOX-1
Subjects: 600 Technology > 08 Food technology > 16 Nutritive value > 05 Enzymes
Divisions: Fermentation Technology and Bioengineering
Protein Chemistry and Technology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 22 Mar 2018 07:03
Last Modified: 11 Oct 2018 06:56
URI: http://ir.cftri.res.in/id/eprint/2111

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