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Aluminium in Alzheimer's disease: are we still at a crossroad?

Gupta, Veer Bala and Anitha, S. and Hegde, M. L. and Zecca, L. and Garruto, R. M. and Ravi, R. and Shankar, S. K. and Stein, R. and Shanmugavelu, P. and Jagannatha Rao, K. S. (2005) Aluminium in Alzheimer's disease: are we still at a crossroad? CMLS, Cellular and Molecular Life Sciences, 62 (2). pp. 143-158. ISSN 1420-682X

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Abstract

Aluminium, an environmentally abundant non-redox trivalent cation has long been implicated in the pathogenesis of Alzheimer's disease (AD). However, the definite mechanism of aluminium toxicity in AD is not known. Evidence suggests that trace metal homeostasis plays a crucial role in the normal functioning of the brain, and any disturbance in it can exacerbate events associated with AD. The present paper reviews the scientific literature linking aluminium with AD. The focus is on aluminium levels in brain, region-specific and subcellular distribution, its relation to neurofibrillary tangles, amyloid beta, and other metals. A detailed mechanism of the role of aluminium in oxidative stress and cell death is highlighted. The importance of complex speciation chemistry of aluminium in relation to biology has been emphasized. The debatable role of aluminium in AD and the cross-talk between aluminium and genetic susceptibility are also discussed. Finally, it is concluded based on extensive literature that the neurotoxic effects of aluminium are beyond any doubt, and aluminium as a factor in AD cannot be discarded. However, whether aluminium is a sole factor in AD and whether it is a factor in all AD cases still needs to be understood.

Item Type: Article
Uncontrolled Keywords: Neurofibrillary tangles; Amyloid beta; Oxidative stress; Cell death; genetics.
Subjects: 600 Technology > 08 Food technology > 11 Food Biochemistry
Divisions: Dept. of Biochemistry
Depositing User: Users 197 not found.
Date Deposited: 03 Jun 2011 10:29
Last Modified: 30 Jun 2015 12:28
URI: http://ir.cftri.com/id/eprint/2007

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