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Amyloid beta and neuromelanin--toxic or protective molecules? The cellular context makes the difference.

Jaganatha Rao, K. S. and Hegde, M. L. and Anitha, S. and Musicco, M. and Zucca, F. A. and Turro, N. J. and Zecca, L. (2006) Amyloid beta and neuromelanin--toxic or protective molecules? The cellular context makes the difference. Progress in Neurobiology, 78 (6). pp. 364-373. ISSN 0301-0082

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Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) share several pathological mechanisms. The parallels between amyloid beta (Abeta) in AD and alpha-synuclein in PD have been discussed in several reports. However, studies of the last few years show that Abeta also shares several important characteristics with neuromelanin (NM), whose role in PD is emerging. First, both molecules accumulate with aging, the greatest risk factor for AD and PD. Second, in spite of their different structures, Abeta and NM have similar characteristics that could also lead to neuroprotection. Metals are required to catalyze their formation and they can bind large amounts of these metals, generating stable complexes and thus playing a protective role against metal toxicity. Moreover, they may be able to remove toxic species such as oligopeptides and excess cytosolic dopamine. Third, both Abeta and NM have been implicated in parallel aspects of the neuronal death that underlies AD and PD, respectively. For example, both molecules can activate microglia, inducing release of toxic factors such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and nitric oxide (NO). A careful analysis of these parallel effects of Abeta and NM, including their seemingly paradoxical ability to participate in both cell death and protection, may lead to an improved understanding of the roles of these molecules in neurodegeneration and also provide insights into possible parallels in the pathological mechanisms underlying AD and PD.

Item Type: Article
Uncontrolled Keywords: Amyloid; Neuromelanin; Toxicity
Subjects: 600 Technology > 08 Food technology > 12 Allergy & Toxicology
600 Technology > 08 Food technology > 11 Food Biochemistry
500 Natural Sciences and Mathematics > 07 Life Sciences
Divisions: Dept. of Biochemistry
Depositing User: Users 16 not found.
Date Deposited: 19 Jul 2011 06:31
Last Modified: 28 Jun 2016 08:08
URI: http://ir.cftri.com/id/eprint/1935

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