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Glycosides and amino acyl esters of carbohydrates as potent inhibitors of angiotensin converting enzyme.

Lohith, K. and Vijayakumar, G. R. and Somashekar, B. R. and Sivakumar, R. and Divakar, S. (2006) Glycosides and amino acyl esters of carbohydrates as potent inhibitors of angiotensin converting enzyme. European Journal of Medicinal Chemistry, 41 (9). pp. 1059-72. ISSN 0223-5234

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Abstract

About 12 glycosides prepared through amyloglucosidase catalysis and 23 amino acyl esters of carbohydrates prepared through lipase catalysis in organic solvents showed angiotensin converting enzyme (ACE) inhibition activity. Both amino acyl esters of carbohydrates and glycosides exhibited IC50 values for ACE inhibition in the 0.5 mM to 15.7 mM range. Eugenyl-D-glucoside (IC50: 0.5+/-0.04 mM), L-isoleucyl-D-glucose (IC50: 0.7+/-0.067 mM), vanillyl-D-sorbitol (IC50: 0.8+/-0.09 mM), L-histidyl-D-fructose (IC50: 0.9+/-0.087 mM), L-tryptophanyl-D-fructose (IC50: 0.9+/-0.092 mM), octyl-D-glucoside (IC50: 1.0+/-0.093 mM), vanillyl-D-mannoside (IC50: 1.0+/-0.089 mM), L-valyl-D-mannitol (IC50: 1.0+/-0.092 mM) and L-phenylalanyl-D-glucose (IC50: 1.0+/-0.089 mM) were the compounds, which showed the best ACE inhibitory activities.

Item Type: Article
Uncontrolled Keywords: Glycosides; Amino acyl esters of carbohydrates; Enzymatic synthesis; ACE inhibition; IC50 values
Subjects: 600 Technology > 08 Food technology > 16 Nutritive value > 01 Carbohydrates
Divisions: Fermentation Technology and Bioengineering
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 05 Aug 2008 10:00
Last Modified: 03 Jul 2015 12:33
URI: http://ir.cftri.com/id/eprint/1934

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