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Sclerotiorin from Penicillium frequentans, a potent inhibitor of aldose reductase.

Chidananda, C. and Jaganmohan Rao, L. and Sattur, A. P. (2006) Sclerotiorin from Penicillium frequentans, a potent inhibitor of aldose reductase. Biotechnology Letters, 28 (20). pp. 1633-1636. ISSN 0141-5492

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Abstract

Aldose reductase, the first key enzyme in the polyol pathway, is involved in complications of diabetes. Sclerotiorin, isolated and purified from the fermented broth of Penicillium frequentans, inhibited aldose reductase with an IC(50 )0.4 microM. The inhibitor also showed antibacterial activity against Bacillus spp.

Item Type: Article
Uncontrolled Keywords: Aldose reductase, Diabetes, Hyperglycemia, Inhibitor Penicillium frequentans Æ Sclerotiorin
Subjects: 600 Technology > 08 Food technology > 16 Nutritive value > 05 Enzymes
600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
Divisions: Fermentation Technology and Bioengineering
Plantation Products Spices and Flavour Technology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 03 Mar 2011 05:50
Last Modified: 25 Sep 2018 08:31
URI: http://ir.cftri.com/id/eprint/1921

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