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Effect of the carotenoid-producing alga, Dunaliella bardawil, on CCl4-induced toxicity in rats.

Vanitha, A. and Murthy, K. N. Chidambara and Kumar, Vinod and Sakthivelu, G. and Veigas, J. M. and Saibaba, P. and Ravishankar, G. A. (2007) Effect of the carotenoid-producing alga, Dunaliella bardawil, on CCl4-induced toxicity in rats. International journal of toxicology, 26 (2). pp. 159-67. ISSN 1091-5818

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Dunaliella bardawil is a carotenoid-producing alga that is being considered for use in nutraceuticals. To evaluate potential protective effects of consumption of this alga, rats were treated with two different doses of D. bardawil (2.5 and 5.0 g kg(-1) body weight [bw]) as a biomass suspension daily for 14 days. Animals were tested against Carbon tetrachloride (CCl4; 2 ml kg(-1))-induced liver toxicity as measured by various biochemical marker enzymes in liver and blood. All measurements were taken 6 h following the single dose of CCl4. The results of this study show that there was a slight, but statistically significant mean serum enzyme values, with D. bardawil treatment, compared to higher mean values in animals receiving CCl4 alone. Lipid peroxidation is measured by thiobarbituric acid-reactive substance (TBARS) activity was likewise slightly less elevated with algae treatment. The results also demonstrated protection against DNA strand breaks in hepatocytes, as measured by single cell gel electrophoresis. Liver histopathology was less severe with D. bardawil treatment, supporting the apparent protective action of 14-day treatment on hepatic oxidative injury.

Item Type: Article
Uncontrolled Keywords: CCl4, DNA Damage, Dunaliella bardawil, Hepatoprotection, Synthetic β-Carotene
Subjects: 600 Technology > 01 Medical sciences > 17 Toxicology
500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 01 Algae
Divisions: Dept. of Biochemistry
Plant Cell Biotechnology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 12 Aug 2008 07:21
Last Modified: 27 Oct 2018 11:09
URI: http://ir.cftri.com/id/eprint/1870

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