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α-1-Antitrypsin: Sequence Analysis and Homology Modeling

Deepthi, S.G (2007) α-1-Antitrypsin: Sequence Analysis and Homology Modeling. [Student Project Report]

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Abstract

This Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page.

Item Type: Student Project Report
Additional Information: The aim of the present study was to gain an insight into the phylogenetic relationships, the conserved sequence domains and the three dimensional aspects of ovine α-1-PI and analyse it with respect to the function. Heparin and trypsin appear to bind α-1-PI in a non-competitive manner Heparin binding has been shown to cause a conformational change that results in activation of antithrombin as an inhibitor. The study projects to look into whether heparin binding to α-1-PI by molecular docking activates α-1-PI and causes changes if any in its structure..
Uncontrolled Keywords: alpha 1 anitrypsin sequence analysis homology modeling
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 29 Protein Chemistry
Divisions: Protein Chemistry and Technology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 04 Mar 2008 09:32
Last Modified: 28 Dec 2011 09:32
URI: http://ir.cftri.com/id/eprint/1664

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