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Effect of curcumin and eugenol on iron-induced in rats hepatic toxicity

Pulla Reddy, A. C. and Lokesh, B. R. (1996) Effect of curcumin and eugenol on iron-induced in rats hepatic toxicity. Toxicology, 107. pp. 39-45.

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Abstract

Male Wistar rats injected i.p. with 30 mg Fe’+ikg body weight show hepatic damage as measured by an increase in lipid peroxides which correlated with elevated serum enzymes, alanine aminotransferase (ALAT), aspartate amino- transferase (ASAT) and lactate dehydrogenase (LDH). Oral administration of spice principles, curcumin from turmeric (30 mgkg body weight) or eugenol from cloves (100 mgkg body weight), for 10 days lowered the liver and serum lipid peroxide levels, serum ALAT, ASAT and LDH, enhanced by i.p. injection of iron. This study indicates that curcumin or eugenol reduces the iron-induced hepatic damage by lowering lipid peroxidation.

Item Type: Article
Uncontrolled Keywords: Iron; Hepatic toxicity; Lipid peroxidation; Curcumin and eugenol
Subjects: 600 Technology > 08 Food technology > 30 Spices/Condiments
500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 11 Lipid Biochemistry
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 11 Oct 2007 09:58
Last Modified: 29 Dec 2016 13:16
URI: http://ir.cftri.com/id/eprint/1496

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