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Facile CAN catalyzed one pot synthesis of novel indol-5,8-pyrimido[4,5- d ]pyrimidine derivatives and their pharmacological study.

Venkatesh, T. and Yadav, D. Bodke and Aditya Rao, S. J. (2020) Facile CAN catalyzed one pot synthesis of novel indol-5,8-pyrimido[4,5- d ]pyrimidine derivatives and their pharmacological study. Chemical Data Collections, 25. pp. 1-13.

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Abstract

In the present work a novel series of indol-5,8-pyrimido[4,5- d ]pyrimidine derivatives ( 4a-l ) have been synthesized by Biginelli reaction of barbituric/thiobarbituric acid, sub- stituted indole-3-carboxaldehyde and substituted aryl amines in aqueous ethanol using 10 mol% CAN as a catalyst. The synthesized compounds ( 4a-l) were evaluated for in vitro an- tibacterial and anticancer activities. In addition to this, in silico molecular docking studies was also performed to predict the binding interactions of synthetic molecules with appro- priate target molecules in connection to their antimicrobial and anti-cancer effects. Among the compounds tested, compounds 4d, 4 g and 4 h were found to have effective antibac- terial activity against the tested pathogens. The cytotoxicity studies of synthesized pyrimi- dine derivatives were found to be effective against K-562, HeLa, MCF-7 and Hepg-2 cancer cell lines.

Item Type: Article
Uncontrolled Keywords: Pyrimidines Antibacterial Cytotoxicity Molecular docking
Subjects: 600 Technology > 01 Medical sciences > 15 Pharmacology
Divisions: Plant Cell Biotechnology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 30 Apr 2020 06:40
Last Modified: 30 Apr 2020 06:40
URI: http://ir.cftri.com/id/eprint/14273

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