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Safety efficacy and chemical profiling of water-soluble Talaromyces purpureogenus CFRM02 pigment.

Saritha, G. Pandit and Mohan Kumari, H. P. and Muthukumar, S. P. and Mohan, A. Dhale (2020) Safety efficacy and chemical profiling of water-soluble Talaromyces purpureogenus CFRM02 pigment. Food Chemistry, 310. pp. 1-8. ISSN 0308-8146

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Abstract

Talaromyces purpureogenus CFRM02 pigments are non-toxic to Artemia franciscana. Further, in acute toxicity study, single dose (50, 300, 1000 and 2000 mg/kg body weight) pigment was administered to female Wistar rats. After 14 days, no evidence of adverse effect on body weight, mortality and clinical signs were observed. Similarly, 28 days sub-acute studies (250–1000 mg/kg body weight) showed no significant changes in food intake, body weight gain and relative weight of vital organs. No signs of toxicity on biochemical, hematological parameters. Histopathological examination of the liver and kidney were normal. There were no marked changes in any of the serum enzymes activities. There were no significant changes in treated and control group (acute and sub-acute). The HRMS data revealed the identification of purpuride, PP-O, PP-R, pentalsamonin, puractin-A, arginine-monascorubrin, purpurquinone-A, ankaflavin, purpactin-C. These results confirmed safety efficacy of T. purpureogenus CFRM02 pigment and suggested applications in food and nutraceuticals.

Item Type: Article
Uncontrolled Keywords: Talaromyces purpureogenus Toxicity Pigment Chemical profiling HRMS
Subjects: 600 Technology > 01 Medical sciences > 17 Toxicology
600 Technology > 08 Food technology > 29 Microbiological food > 04 Yeast
Divisions: Dept. of Biochemistry
Fermentation Technology and Bioengineering
Grain Science and Technology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 27 Apr 2020 10:32
Last Modified: 27 Apr 2020 10:32
URI: http://ir.cftri.com/id/eprint/14267

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