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Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: behavioural and biochemical evidence.

Sriranjini, Venkata Rao and Hemalatha, P. and Yetish, S. and Muralidhara, M. and Rajini, P. S. (2019) Prophylactic neuroprotective propensity of Crocin, a carotenoid against rotenone induced neurotoxicity in mice: behavioural and biochemical evidence. Metabolic Brain Disease, 34. pp. 1341-1353.

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Abstract

Previously we have demonstrated the potential neuroprotective propensity of saffron and Crocin (CR) employing a Drosophila model of Parkinsonism. Rotenone (ROT) has been extensively used as a model neurotoxin to induce Parkinson’s disease (PD) likesymptomsinmice.In the present study,as a proof of conceptweevaluatedtheefficacyofCRprophylaxis(25mg/kgbw/d, 7d) toattenuate ROT(0.5mg/Kg bw/d,7d) -inducedneurotoxiceffects inmalemicefocussing onneurobehaviouralassessments andbiochemical determinantsinthestriatum.CRprophylaxissignificantlyalleviatedROT-inducedbehaviouralalterationssuch as increased anxiety, diminished exploratory behaviour, decreased motor co-ordination, and grip strength. Concomitantly, we evidenceddiminutionofoxidative stressmarkers,enhancedlevelsofantioxidant enzymeand mitochondrialenzymefunctionin the striatalregion. Further, varying degreeofrestoration ofcholinergic function, dopamineand α-synucleinlevelswerediscerniblesuggestingthepossiblemechanism/sofactionofCRinthismodel.Basedonourearlierdatainfliesandinwormmodel,we propose its use as an adjuvant therapeutic agent in oxidative stress-mediated neurodegenerative conditions such as PD.

Item Type: Article
Uncontrolled Keywords: Crocin Neuroprotection Rotenone Parkinson’sdisease Neurotoxicity
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 14 Carotenoid Chemistry
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Dept. of Biochemistry
Food Protectants and Infestation Control
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 27 Feb 2020 06:01
Last Modified: 27 Feb 2020 06:01
URI: http://ir.cftri.com/id/eprint/14220

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