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Gastro-protective potentials of Spirulina: role of vitamin B12.

Kumudha, A. and Shylaja, M. Dharmesh and Sarada, R. (2020) Gastro-protective potentials of Spirulina: role of vitamin B12. Journal of Food Science and Technology, 57. pp. 745-753. ISSN 0022-1155

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Abstract

Gastric ulcer is a chronic health problem world over. Spirulina is known to contain significant amounts of vitamin B12 hence Spirulina was evaluated for gastroprotective properties against gastric ulcerations. Spirulina biomass (SB) and Spirulina extract (SE) were evaluated in swim stress induced gastric ulcers in adult male albino rats. Both SB and SE inhibited 45% and 60% of ulcers formation induced by swim stress respectively. Gastroprotection has been elucidated to be due to inhibition of (a) upregulated H?,K?-ATPase activity that induced ulcer condition; (b) lipid peroxidation and (c) altered antioxidant enzyme levels. The data highlighted the importance of vitamin B12 in protecting the gut against gastric ulcerations and suggested that both Spirulina biomass and Spirulina extract contain bioavailable B12. Spirulina based product/food can be used as alternatives to gastroprotective agents that are known to cause acidity themselves upon long term use.

Item Type: Article
Uncontrolled Keywords: Spirulina Vitamin B12 Gastric ulcer Deficiency of vitamin B12
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 01 Algae
600 Technology > 08 Food technology > 16 Nutritive value > 04 Vitamins
Divisions: Dept. of Biochemistry
Plant Cell Biotechnology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 27 Feb 2020 05:54
Last Modified: 27 Feb 2020 05:54
URI: http://ir.cftri.com/id/eprint/14219

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