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Inhibition of thrombin, an unexplored function of retinoic acid.

Anantha Krishna, Tirumala Harikrishna and Kamalraj, Subban and Maheswaraiah, Anikisetty and Akhilender Naidu, K. (2019) Inhibition of thrombin, an unexplored function of retinoic acid. Biochemistry and Biophysics Reports, 18. pp. 1-5.

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Abstract

Retinoic acid, a derivative of vitamin A, is known to possess in vivo anti-inflammatory, anti-platelet and fibrinolytic activities. We have investigated the in vitro thrombin and platelet aggregation inhibitory activities of vitamin A (retinol) and its derivatives, retinoic acid and retinaldehyde. The thrombin enzymatic assay was performed fluorimetrically to assess the inhibition of thrombin (Sigma and plasma). Retinoic acid, retinaldehyde and retinol exhibited potent inhibition of thrombin, with IC50 values of 67μg/ml, 74μg/ml and 152μg/ml, respectively for the inhibition of thrombin (Sigma); and 49μg/ml, 74μg/ml and 178μg/ml, respectively for the inhibition of thrombin (plasma). Amongst vitamin A and its derivatives, retinoic acid showed the highest inhibition of both the forms of thrombin. Vitamin A and its derivatives also displayed remarkable inhibition of platelet aggregation. This is the first report of vitamin A and its derivatives showing inhibition of thrombin and platelet aggregation in vitro.

Item Type: Article
Uncontrolled Keywords: Retinoic acid Retinaldehyde Retinol Thrombin inhibition Platelet aggregation inhibition
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 25 Peptide Chemistry
600 Technology > 08 Food technology > 16 Nutritive value > 04 Vitamins
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 31 May 2019 04:18
Last Modified: 31 May 2019 04:25
URI: http://ir.cftri.com/id/eprint/14095

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