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Sesaminol diglucoside, a water-soluble lignan from sesame seeds induces brown fat thermogenesis in mice.

Anusha, J. and Usharani, D. and Malathi, Srinivasan and Ram, Rajasekharan (2018) Sesaminol diglucoside, a water-soluble lignan from sesame seeds induces brown fat thermogenesis in mice. Biochemical and Biophysical Research Communications, 507 (1-4). pp. 155-160. ISSN 0006-291X

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Abstract

Brown adipose tissue (BAT) is the site of non-shivering thermogenesis in mammals, wherein energy is dissipated as heat. We observed that aqueous extract of black sesame seed triggers an increase in the expression of Uncoupling Protein 1 (UCP1) in brown adipocytes from mice. The active component from the extract was purified and identified to be sesaminol diglucoside (SDG). SDG treatment decreased mass of white fat pads and serum glucose levels and increased UCP1 levels in BAT thereby protecting mice against high fat induced weight gain. Further in silico and in vitro studies revealed that these effects are due to the agonist like behaviour of SDG towards beta 3 adrenergic receptors (b3-AR). Together, our results suggest that SDG induces BAT mediated thermogenesis through b3-AR and protects mice against diet-induced obesity.

Item Type: Article
Uncontrolled Keywords: Sesame Sesaminol diglucoside Brown adipose tissue Uncoupling protein 1 b3 adrenergic receptor
Subjects: 600 Technology > 08 Food technology > 19 Lipids-oils/fats > 01 Oilseeds
Divisions: Dept. of Lipid Science
Food Safety Analytical Quality Control Lab
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 05 Feb 2019 06:06
Last Modified: 05 Feb 2019 06:06
URI: http://ir.cftri.com/id/eprint/13919

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