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In vitro anti-inflammatory activity among probiotic Lactobacillus species isolated from fermented foods.

Manjulata Devi, S. and Kurrey, N. K. and Prakash, M. Halami (2018) In vitro anti-inflammatory activity among probiotic Lactobacillus species isolated from fermented foods. Journal of Functional Foods, 47. pp. 19-27. ISSN 1756-4646

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Abstract

Probiotic bacteria have the ability to alter immune response conferring treatment to inflammatory diseases. In the current study, probiotic Lactobacillus strains were subjected to adhesion to epithelial Caco-2 cells. Subsequently, gene expression of pro-and anti-inflammatory genes were studied under three stimulation conditions (which includes LPS-challenge, stress induction and pathogens invasion). Herein, immunomodulatory activity of native Lactobacillus strains (n=3) were compared to L. rhamnosus GG. The studied strains had downregulated the gene expression of pro-inflammatory cytokines (CKs) (like TNF-α, IL-1α, IL-1β, IL-6 and IL-8) and up-regulated the anti-inflammatory CKs like TGFβ1, IL-4, and IL-10. Gene expression of TLR2 has also been noted. Strain-specific interactions were noticed during the different probiotic treatment. Further, phylogenetic dendrogram of mucin adhesion domain suggested the interaction of Lactobacillus and Listeria species, explaining competitive colonization and exclusion mechanism in an ecological niche. Overall, isolate L. paraplantarum MTCC 9483 has effectively modulated induced conditions by its anti-inflammatory activity.

Item Type: Article
Uncontrolled Keywords: Probiotics Caco-2 cells Immune response Pathogen invasion Immunomodulation Anti-inflammatory activity
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 02 Bacteriology
600 Technology > 08 Food technology > 18 Processed foods > 02 Fermented foods
Divisions: Fermentation Technology and Bioengineering
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 19 Sep 2018 06:48
Last Modified: 19 Sep 2018 06:48
URI: http://ir.cftri.com/id/eprint/13854

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