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Effect of zinc deprivation on the lipid metabolism of budding yeast.

Neelima, Singh and Kamlesh Kumar, Yadav and Ram, Rajasekharan (2017) Effect of zinc deprivation on the lipid metabolism of budding yeast. Current Genetics, 63. pp. 977-982.

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Abstract

Zinc is an essential micronutrient for all living cells. It serves as a structural and catalytic cofactor for numerous proteins, hence maintaining a proper level of cellular zinc is essential for normal functioning of the cell. Zinc homeostasis is sustained through various ways under severe zinc-deficient conditions. Zinc-dependent proteins play an important role in biological systems and limitation of zinc causes a drastic change in their expression. In budding yeast, a zinc-responsive transcription factor Zap1p controls the expression of genes required for uptake and mobilization of zinc under zinc-limiting conditions. It also regulates the polar lipid levels under zinc-limiting conditions to maintain membrane integrity. Deletion of ZAP1 causes an increase in triacylglyerol levels which is due to the increased biosynthesis of acetate that serves as a precursor for triacylglycerol biosynthesis. In this review, we expanded our recent work role of Zap1p in nonpolar lipid metabolism of budding yeast.

Item Type: Article
Uncontrolled Keywords: Micronutrients · Zinc limitation · Zinc homeostasis · Nonpolar lipids · Polar lipids
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 22 Lipid Chemistry
500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 19 Yeast
Divisions: Dept. of Lipid Science
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 20 Feb 2018 06:49
Last Modified: 20 Feb 2018 06:49
URI: http://ir.cftri.com/id/eprint/13434

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