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Engineered small intestinal system as an alternative to in-situ intestinal permeability model.

Parthasarathi, S. and Anu Bhushani, J. and Anandharamakrishnan, C. (2018) Engineered small intestinal system as an alternative to in-situ intestinal permeability model. Journal of Food Engineering, 222. pp. 110-114. ISSN 0260-8774

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Abstract

Intestinal permeability is the most important factor that determines the bioavailability. In-vitro techniques like Caco-2 model and Ussing chamber are used for evaluating the intestinal permeability of the bioactive compound. But the lack of mucosal layer in those models makes the intestinal absorption prediction less accurate. We developed an engineered small intestinal system to evaluate intestinal permeability of bioactive compound. Following this approach, we have evaluated the intestinal permeability of fat soluble and water soluble bioactive compound and compared with in situ single-pass intestinal perfusion technique.

Item Type: Article
Uncontrolled Keywords: Effective permeability Single-pass intestinal perfusion
Subjects: 600 Technology > 01 Medical sciences > 09 Human Physiology
Divisions: Food Engineering
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 14 Feb 2018 06:46
Last Modified: 14 Feb 2018 06:46
URI: http://ir.cftri.com/id/eprint/13411

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