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Biocompatible lutein-polymer-lipid nanocapsules: Acute and subacute toxicity and bioavailability in mice.

Arunkumar, R. and Ravi, Hindupur. and Baskaran, V. (2016) Biocompatible lutein-polymer-lipid nanocapsules: Acute and subacute toxicity and bioavailability in mice. Materials Science and Engineering C, 69. pp. 1318-1327.

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Abstract

Lutein-poly-(lactic-co-glycolic acid) (PLGA)-phospholipid (PL) nanocapsules were prepared (henceforth referred as lutein nanocapsules) and studied for acute, subacute oral toxicity and bioavailability of lutein in mice. Prior to examining the safety of lutein nanocapsules, particle size, zeta potential, surface morphology and interaction between lutein, PLGA and PL were studied. In acute study, mice were gavaged with a single dose of lutein nanocapsules at 0.1, 1, 10 and 100 mg/kg body weight (BW) and examined for 2 weeks,while in subacute study, daily micewere gavagedwith a dose of 1 and 10 mg/kg BWfor 4weeks. Results revealed that mean size and zeta value of lutein nanocapsuleswere 140nmand−44mV, respectively. Acute and subacute toxicity studies did not show any mortality or treatment related adverse effect in clinical observations, ophthalmic examinations, body and organ weights. No toxicity related findings were observed in hematology, histopathology and other blood and tissue clinical chemistry parameters. In subacute study, no observed adverse effect level (NOAEL) of lutein nanocapsules was found to be at a dose of 10 mg/kg BW. Feeding lutein nanocapsules resulted in a significant (p b 0.01) increase in lutein level in plasma and tissue compared to the control group. Lutein nanocapsules did not cause toxicity in mice. However, human trials are warranted.

Item Type: Article
Uncontrolled Keywords: Biocompatible Carotenoids Lutein Nanocapsules PLGA Phospholipid Toxicity
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 14 Carotenoid Chemistry
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 22 Jan 2018 05:55
Last Modified: 23 Jan 2018 06:57
URI: http://ir.cftri.com/id/eprint/13358

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