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Minor Constituents in Rice Bran Oil and Sesame Oil Play a Significant Role in Modulating Lipid Homeostasis and Inflammatory Markers in Rats.

Poorna Chandra Rao, Yalagala and Sugasini, D. and Ramaprasad, T. R. and Lokesh, B. R. (2017) Minor Constituents in Rice Bran Oil and Sesame Oil Play a Significant Role in Modulating Lipid Homeostasis and Inflammatory Markers in Rats. Journal of Medicinal Food, 20 (7). pp. 1-11. ISSN 1096-620X

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Abstract

The effects of feeding rats with groundnut oil (GNO), rice bran oil (RBO), and sesame oil (SESO) on serum lipids, liver lipids, and inflammatory markers were evaluated in rats. Male Wistar rats were fed with AIN-93 diet supplemented with 10 wt% of GNO, RBO, and SESO in the form of native (N) and minor constituent-removed (MCR) oils. Rats given RBO and SESO showed significant reduction in serum and liver lipids, 8-hydroxy-2-deoxyguanosine, cytokines in liver, and eicosanoids in leukocytes as compared with the rats given GNO and MCR oils. The rats fed with native oils of RBO and SESO showed an upregulation of sterol regulatory element-binding protein (SREBP)-2 and peroxisome proliferator-activated receptor gamma (PPARc) and downregulation of nuclear factor-kappa B (NF-jB) p65. These effects of native oil were significantly compromised when rats were given MCR oils. In conclusion, the minor constituents significantly support the hypolipidemic and anti-inflammatory properties of RBO and SESO.

Item Type: Article
Uncontrolled Keywords: hypocholesterolemic effects � inflammatory mediators � minor constituents � oxidative stress markers � rice bran oil � sesame oil
Subjects: 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
600 Technology > 08 Food technology > 19 Lipids-oils/fats
Divisions: Dept. of Biochemistry
Lipid Science and Traditional Foods
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 18 Jan 2018 07:06
Last Modified: 18 Jan 2018 07:06
URI: http://ir.cftri.com/id/eprint/13308

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