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Oral Supplementation of GABA Containing Rice Flour Alleviate Acrylamide Induced Oxidative Impairments and Neurotoxicity in Mice.

Divyashri, G. and Gokul, K. and Dr., Muralidhara and Prapulla, S. G. (2017) Oral Supplementation of GABA Containing Rice Flour Alleviate Acrylamide Induced Oxidative Impairments and Neurotoxicity in Mice. EC Nutrition, 8 (6). pp. 191-203.

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Abstract

Endogenous antioxidant cycle play a pivotal role in the prevention of damage induced by free radicals. An imbalance between the production and removal of free radicals and reactive oxygen species (ROS) enhances the rate of oxidative stress. Oxidative stress play a major role in the development of neurodegerative diseases. Antioxidants are now being looked as a therapeutic agents, as they have ability to neutralize free radicals. Rice, being the staple food for nearly 50% of world’s population, play a vital role in the concentration of antioxidants ingested daily. The present study was designed to investigate antioxidative and neuroprotective effect of gammaaminobutyric acid (GABA) containing fermented rice flour (GFRF) in acrylamide (ACR) acrylamide (ACR) induced oxidative stress mice model. GFRF contained 750.55 ± 26.03 mg GABA/100g DM under optimized conditions and fermentation enhanced the levels of antioxidant phenolics in GFRF (unpublished data). ACR administration caused significant oxidative stress as evident by increased ROS, protein carbonyls, nitric oxide and malondialdehyde levels in cortex and cerebellum clearly suggesting significant oxidative stress in vivo. Mice supplemented with GFRF orally, diminished oxidative markers, increased the activities of antioxidant enzymes in cortex and cerebellum brain region with concomitant increase in GABA levels, conferring neuroprotection against ACR induced oxidative stress. Our data suggest that antioxidative and neuroprotective effects exerted by GFRF are mediated through decreases in free-radical generation and increases in activities of superoxide dismutase (SOD) and catalase (CAT) in vivo.

Item Type: Article
Uncontrolled Keywords: Antioxidants; Reactive Oxygen Species; Gamma-Aminobutyric Acid; Neuroprotection; GABA Containing Fermented Rice Flour
Subjects: 600 Technology > 01 Medical sciences > 17 Toxicology
600 Technology > 08 Food technology > 21 Cereals > 01 Rice
Divisions: Dept. of Biochemistry
Fermentation Technology and Bioengineering
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 18 Jan 2018 06:18
Last Modified: 18 Jan 2018 06:18
URI: http://ir.cftri.com/id/eprint/13301

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