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Antihyperlipidemic activity of Cassia auriculata flower extract in oleic acid induced hyperlipidemia in Saccharomyces cerevisiae.

Vijayakumar, Rajendran and Anilkumar, Krishnegowda and Vasanthi, Nachiappan (2017) Antihyperlipidemic activity of Cassia auriculata flower extract in oleic acid induced hyperlipidemia in Saccharomyces cerevisiae. Journal of Food Science and Technology, 54 (9). pp. 2965-2972. ISSN 0022-1155

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Abstract

The Cassia auriculata herb has been traditionally used in India for medicinal purposes to treat hyperglycemia, diabetes, rheumatism, asthma, and skin diseases. In the present study, ethanolic extract of Cassia auriculata flower (Et-CAF) depicted anti-hyperlipidemic effect in the budding yeast cells. The hyperlipidemic conditions were induced in the yeast cells with oleic acid which showed an increase in triacylglycerol (TAG) and sterol esters (SE), and was supported by the mRNA expression of LRO1 and DGA1 (involved in TAG formation); as well as ARE1 and ARE2 (involved in SE formation). The antihyperlipidemic effect by the Et-CAF was compared with the commercial drug Atorvastatin. The lipid droplets were increased in the hyperlipidemic yeast cell that was observed under the confocal microscope with BODIPY staining; Atorvastatin and Et-CAF reduced the lipid droplets. This study revealed that the anti-hyperlipidemic effect in Et-CAF has gained importance and might be used to fill the gap created by the allopathic drugs.

Item Type: Article
Uncontrolled Keywords: Cassiaauriculata flower � Hyperlipidemia � Neutral lipids � Saccharomyces cerevisiae � Triacylglycerol � Sterol esters � Lipid droplets
Subjects: 600 Technology > 03 Agriculture > 04 Medicinal Plants
Divisions: Plantation Products Spices and Flavour Technology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 21 Nov 2017 06:12
Last Modified: 21 Nov 2017 06:12
URI: http://ir.cftri.com/id/eprint/13141

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