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Polymer-lipid nanocarriers to improve stability, bioavailability and anti-cancer property of carotenoid fucoxanthin.

Ravi, H. (2016) Polymer-lipid nanocarriers to improve stability, bioavailability and anti-cancer property of carotenoid fucoxanthin. Doctoral thesis, Central Food Technological Research Institute.

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Abstract

Fucoxanthin (FUCO), a xanthophyll carotenoid is photo-, and thermo-labile and poorly bioavailable due to its lipophilicity. Stability and bioavailability of FUCO can be improved by its encapsulation with a suitable polymer matrix and specific lipid. Hence, nanoencapsulated FUCO was prepared using chitosan (CS) - sodium tripolyphosphate (TPP) - glycolipid (GL) multifaceted system (CS-NGs) by means of ionic gelation method. It was hypothesized that nanoencapsulated FUCO in CS-NGs+GL matrix may favour its intestinal uptake and intracellular trafficking with no toxicity. It was aimed that GL and FUCO may be an agonist to PPARγ and SRB1 which may result in active intestinal uptake of FUCO besides passive uptake.

Item Type: Thesis (Doctoral)
Uncontrolled Keywords: Fucoxanthin chitosan carotenoids anticancer
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 14 Carotenoid Chemistry
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 13 Jul 2017 06:59
Last Modified: 13 Jul 2017 06:59
URI: http://ir.cftri.com/id/eprint/12815

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