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Protective effects of phenolics rich extract of ginger against Aflatoxin B1-induced oxidative stress and hepatotoxicity.

Vipin, A. V. and Raksha, R. K. and Nawneet Kumar, K. and Anu Appaiah, K. A. and Venkateswaran, G. (2017) Protective effects of phenolics rich extract of ginger against Aflatoxin B1-induced oxidative stress and hepatotoxicity. Biomedicine and Pharmacotherapy, 91. pp. 415-424.

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Abstract

Aflatoxin B1 (AFB1) is one of the predominant mycotoxin contaminant in food and feed, causing oxidative stress and hepatotoxicity. Ginger phenolics have been reported for its antioxidant potential and hepatoprotective activity. The present study investigated the protective effects of phenolics rich ginger extract (GE) against AFB1 induced oxidative stress and hepatotoxicity, in vitro and in vivo. The phenolic acid profiles of GE showed 6-gingerol and 6-shogaol as predominant components. Pretreatment of HepG2 cells with GE significantly inhibited the production of intracellular reactive oxygen species (ROS), DNA strand break, and cytotoxicity induced by AFB1. A comparable effect was observed in in vivo. Male Wistar rats were orally treated with GE (100 and 250 mg/kg) daily, with the administration of AFB 1 (200 mg/kg) every alternative day for 28 days. Treatment with GE significantly reduced AFB1 induced toxicity on the serum markers of liver damage. In addition, GE also showed significant hepatoprotective effect by reducing the lipid peroxidation and by enhancing the antioxidant enzymes activities. These results combined with liver histopathological observations indicated that GE has potential protective effect against AFB1 induced hepatotoxicity. Additionally, administration of GE up-regulated Nrf2/HO-1 pathway, which further proved the efficiency of GE to inhibit AFB1 induced hepatotoxicity.

Item Type: Article
Uncontrolled Keywords: Aflatoxin B1 Hepatotoxicity Ginger phenolics Oxidative stress Nrf2
Subjects: 600 Technology > 01 Medical sciences > 17 Toxicology
600 Technology > 08 Food technology > 30 Spices/Condiments
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Dept. of Biochemistry
Food Microbiology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 10 Jul 2017 06:34
Last Modified: 10 Jul 2017 06:34
URI: http://ir.cftri.com/id/eprint/12772

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