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Chitosan-glycolipid nanocarriers improve the bioavailability of fucoxanthin via up-regulation of PPARc and SRB1 and antioxidant activity in rat model.

Ravi, Hindupur. and Baskaran, V. (2017) Chitosan-glycolipid nanocarriers improve the bioavailability of fucoxanthin via up-regulation of PPARc and SRB1 and antioxidant activity in rat model. Journal of Functional Foods, 28. pp. 215-226. ISSN 1756-4646

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Abstract

In this study, we have hypothesized that fucoxanthin (FUCO) absorption from nanogels (NGs) may increase. CS-NGs were prepared by using chitosan (CS) with/without GL and studied (i) the FUCO bioavailability upon a single (48 h), repeated (14 d) and dietary (one month) feeding, (ii) the agonistic property of FUCO and GL on PPARc and SRB1 expressions to examine active absorption of FUCO. In single (pmol/mL/48 h) and repeated dose (nmol/mL) study, plasma FUCO was higher by 38.8, 227.5% and 73.3, 292.4% in CS-NGs + GL compared to CS-NGs (�GL) and control groups. In dietary study, plasma FUCO (nmol/mL) was higher by 57.5, 400 and 287% in CS-NGs + GL compared to CS-NGs (�GL), seaweed and control groups. Increased PPARc expression was evident in CS-NGs + GL group depicting GL and FUCO acts an agonist. This is the first report demonstrating advantage of CS-NGs + GL for improved FUCO bioavailability via passive and active transport through PPARc mediated SRB1 activation.

Item Type: Article
Uncontrolled Keywords: Glycolipid Chitosan Nanogels Fucoxanthin PPARc SRB1
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 14 Carotenoid Chemistry
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 03 Jul 2017 09:14
Last Modified: 03 Jul 2017 09:14
URI: http://ir.cftri.com/id/eprint/12741

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