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Gastro protective and H+, K+-ATPase/H. pylori inhibitory properties of pectic polysaccharides from potato.

Kavitha, B. C. and Shylaja, M. Dharmesh (2016) Gastro protective and H+, K+-ATPase/H. pylori inhibitory properties of pectic polysaccharides from potato. International Journal of Biological Macromolecules, 84. pp. 385-393. ISSN 0141-8130

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Abstract

tPolysaccharide is one among the important classes of biological polymers that is reported to exhibitdisease preventive properties. The present study describes the isolation of galactans and confirmation ofthe same by sugar analysis and determination of anti-ulcer effect of Potato Galactan Polysaccharide (PGP).Data indicated that PGP possessed sugar composition of rhamnose (2%), arabinose (3%), mannose (3%),galactose (94%) and uronic acid (17%) confirming that PGP thus isolated is a galactan. PGP exhibited potentH+, K+-ATPase inhibitory activity (IC50420 �g/mL) in vitro as opposed to lansoprazole, a known antiulcerdrug with IC5019.3 �g/mL. The antiulcer potency of PGP was evaluated in ethanol stress induced gastriculcer model in vivo. About 84% reduction in ulcer index; enhanced mucosal recovery, normalization of H+,K+-ATPase, antioxidant and antioxidant enzymes substantiated the antiulcer potentials of PGP. Mucosalrecovery could be attributed to cytoprotective and DNA protective ability of PGP that can help in mucosallayer regeneration. Further, PGP was also effective in inhibiting Helicobacter pylori as per growth inhibitionassay followed by scanning electron microscopic studies suggesting that PGP is effective in curbing thegrowth of H. pylori, which is responsible for ∼70% of gastric ulcer/cancer incidences.

Item Type: Article
Uncontrolled Keywords: Solanum tuberosum Gastric ulcer Helicobacter pyloria
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 28 Polysaccharide Chemistry
600 Technology > 08 Food technology > 23 Vegetables > 02 Potato
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 30 Jun 2017 08:45
Last Modified: 30 Jun 2017 08:45
URI: http://ir.cftri.com/id/eprint/12721

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