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Effect of Banana (Musa sp. var. elakki bale) Flower and Pseudostem on Antioxidant and Lysosomal Enzyme Activities in Streptozotocin-induced Diabetic Rats.

Jamuna, J. Bhaskar and Puneeth Kumar, A. and Salimath, P. V. (2011) Effect of Banana (Musa sp. var. elakki bale) Flower and Pseudostem on Antioxidant and Lysosomal Enzyme Activities in Streptozotocin-induced Diabetic Rats. Journal of Pharmacy Research, 4 (4). pp. 1087-1091.

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Abstract

Diabetes mellitus is an endocrine metabolic disorder affecting many people all over the world. The mortality rate due to diabetes and its complications is increasing at an alarming rate. Dietary factors rich in nutraceuticals, antioxidants, dietary fiber, etc are of great significance in the management of diabetes. Oxidative stress contributes to the progression of diabetes and its complications and hence the present study was aimed to examine the effect of banana (Musa sp. var. elakki bale) flower and pseudostem on antioxidant and lysosomal enzyme activities during diabetes. Banana flower (5%) and pseudostem (5%) feeding reduced hyperglycemia levels by 40 and 38%, respectively, and modulated the activities of antioxidant defense enzymes viz., catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) in streptozotocin-induced diabetic rats. Activity of SOD was decreased in serum of diabetic group (1.6 ± 0.02 U/mg protein), and was significantly ameliorated in banana flower (1.9 ± 0.03 U/mg protein) and pseudostem (2.0 ± 0.09 U/mg protein) fed groups at P<0.001. An alteration in the activities of lysosomal enzymes viz., N-acetyl-ß-D-glucosaminidase, N-acetyl-ß-D-glucuronidase, N-acetyl-ß-D-galactosidase and acid phosphatase was observed in diabetic group and was modulated by banana flower and pseudostem feeding. Our results indicate that banana flower and pseudostem are involved in minimizing the oxidative stress-induced tissue damage by regulating the altered antioxidant and lysosomal enzyme activities in different tissues during diabetes. These findings suggest that banana flower and pseudostem could be used as source of alternative medicines and nutraceuticals.

Item Type: Article
Uncontrolled Keywords: Diabetes, banana flower, banana pseudostem, antioxidant enzymes, lysosomal enzymes, aminoguanidine
Subjects: 600 Technology > 08 Food technology > 24 Fruits > 02 Banana
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 28 Jun 2017 07:09
Last Modified: 28 Jun 2017 07:09
URI: http://ir.cftri.com/id/eprint/12691

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