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Ferulic Acid Supplements Abrogate Oxidative Impairments in Liver and Testis in the Streptozotocin-Diabetic Rat.

Thyagaraju, B.M and Dr., Muralidhara (2008) Ferulic Acid Supplements Abrogate Oxidative Impairments in Liver and Testis in the Streptozotocin-Diabetic Rat. Zoological Science, 25 (8). pp. 854-860.

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Abstract

The primary objective of this study was to assess the efficacy of ferulic acid (FA), a phenolic antioxidant, in ameliorating oxidative stress in the testis and liver of diabetic pubertal rats. Male (6 wk old) rats were rendered diabetic by an acute dose (60 mglkg body weight, intraperitoneal) of streptozotocin (STZ) and were given oral supplementation of FA (50 mglkg body weightld on alternate days) for 4 weeks, The protective efficacy of FA was assessed by measuring markers of oxidative stress in the testis and liver along with the effect of stress on lipid profile in serum/testis. Terminally, the testis (cytosol and mitochondria) of STZ-administered rats exhibited a marked elevafion in the status of tpid peroxidation and enhanced reactive oxygen species (ROS) production compared to the non-",\,abetic controls, FA treatment completely normalized the oxidative impairments in the testis. Further, STZ-induced depletion of re'duced glutathione (GSH) and elevated proleiti carbonyl conte"t in the testis were restored to normalcy by FA treatment. The protective effects of FA were also discernible in the testis in terms of restoration of activilies of various antioxidant enzymes in the diabetic rats. Furthermore, STZ-induced oxidative impainnents in the liver were also abrogated significantly by FA treatment. STZ-induced perturbations in serum and testicular lipid profiles in the diabetic rats were also significantly aHenuated by FA treatment. Collectively, these results indicate that oral supplementation of FA can significantly mitigate diabetes-associated oxidative impairments in the testis as well as in the liver and suggests the efficacy of FA as a complementary therapeutic agent in the management of diabetes-associated oxidative stress-mediated complications.

Item Type: Article
Uncontrolled Keywords: ferulic acid. streptozotocin. OXidative impairments, testis,liver, pubertal rats
Subjects: 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 27 Jun 2017 11:15
Last Modified: 27 Jun 2017 11:15
URI: http://ir.cftri.com/id/eprint/12683

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