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Fruit extracts of Basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cells

Sravan Kumar, Sandopu and Manoj, Prabhakaran and Giridhar, P. (2015) Fruit extracts of Basella rubra that are rich in bioactives and betalains exhibit antioxidant activity and cytotoxicity against human cervical carcinoma cells. Journal of Functional Foods, 15. pp. 509-515. ISSN 1756-4646

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Abstract

Fruit extracts of Basella rubra, which are rich in bioactive phenolics, flavonoids and betalains were investigated for their antioxidant and anticancer activities against human cervical carcinoma (SiHa) cells. The fruits contained total betalain contents of 0.34 g/100 g fresh weight and 1.9 g/100 g dry weight. Betanin, isobetanin and gomphrenin I were the major pigments identified. Phenolic compounds, such as generic acid, sinapic acid, ferulic acid, coumaric acid and chlorogenic acid, and flavonoids, such as myricetin, quercetin, luteolin, apigenin and kaempferol, were identified. Both water and aqueous methanol extracts of fruits showed significant free radical scavenging potential and ferric reducing antioxidant power. Fruit extracts at 50 mg/mL showed strong (81%) cytotoxic activity against human cervical carcinoma cells.Thus, fruit extracts have potential application for cancer treatments and as nutraceutical or dietary supplements.

Item Type: Article
Uncontrolled Keywords: B. rubra L. Betalains Phenolics Antioxidant Anticancer
Subjects: 600 Technology > 08 Food technology > 23 Vegetables
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Plant Cell Biotechnology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 28 Nov 2016 05:59
Last Modified: 28 Nov 2016 05:59
URI: http://ir.cftri.com/id/eprint/12566

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