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Antioxidant activities of flavidin in different in vitro model systems

Jayaprakasha, G. K. and Jagan Mohan Rao, L. and Sakariah, K. K. (2004) Antioxidant activities of flavidin in different in vitro model systems. Bioorganic and Medicinal Chemistry, 12. pp. 5141-5146.

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Abstract

Flavidin was isolated from Orchidaceae species and purified by silica gel column chromatography. The structure was identified using physical and spectral (1H, 13C NMR, and mass) data. Antioxidant potency of flavidin was investigated employing various established in vitro model systems viz., b-carotene-linoleate, 1,1-diphenyl-2-picryl hydrazyl (DPPH), phosphomolybdenum method, and scavenging of hydrogen peroxide methods. Flavidin showed very good antioxidant activity (90.2%) and almost equivalent to that of BHA at 50ppm level by b-carotene-linoleate method. Radical scavenging activity of flavidin was compared with BHA at 5, 10, 20, and 40ppm concentration and flavidin showed more radical scavenging activity than BHA at all the tested concentrations. Furthermore, flavidin showed very good antioxidant capacity by the formation of phosphomolybdenum complex method. Besides this, flavidin showed effective hydrogen peroxide scavenging activity. The data obtained in the in vitro models clearly establish the antioxidant potency of flavidin. However, comprehensive studies need to be conducted to ascertain the in vivo safety of flavidin in experimental animal models. This is the first report on antioxidant activity of 9,10-dihydro-5H-phenanthro-(4,5 bcd)-pyrans/flavidin type of compounds.

Item Type: Article
Uncontrolled Keywords: Flavidin; Antioxidant activity; Orchidaceae
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 18 Flavonoid Chemistry
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 22 Jun 2007 10:55
Last Modified: 30 May 2012 07:13
URI: http://ir.cftri.com/id/eprint/1254

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