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Methods Integrating Physical Mechanisms Underlying the Food Digestion and Release of Nutrients in Human Stomach

Gopirajah, R. and Anandharamakrishnan, C. (2014) Methods Integrating Physical Mechanisms Underlying the Food Digestion and Release of Nutrients in Human Stomach. Journal of Nutrition and Nutritional Epidemiology, 1 (1). pp. 1-13.

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Abstract

Different models were developed to substitute in vivo studies on gastric digestion of food (for evaluating bioaccessibility) or pharmaceutical formulations (to determine release of active ingredients). However, selecting a suitable method widely depends on operating conditions and how close the model predicts the actual phenomenon occurring. Digestion is well studied in terms of gastric secretion and enzymatic breakdown of food components, but the disintegration kinetics of food and the release of embedded nutrients from the food matrix with effect on various processing conditions still require more attention. This is because, most of the reported models are focused on physiochemical changes during digestion without considering the physical forces exerted on food by accounting actual shape and motility of the stomach. Recently, computational techniques were found to provide unique insight on gastric digestion with its ability to reproduce actual shape and motility of the stomach. All these models help to formulate food and pharmaceuticals. With this background, these comprehensive reviews focustonarrowdown differentgastricmodelsandtheircapabilitieswithmeritsanddemeritstoassistresearchers,manufacturers, and pharmaceutics to select a suitable method for evaluation. This review also includes the latest developments in the area of the computational modeling, particle disintegration, gastric emptying and release of nutrients from food microstructure.

Item Type: Article
Uncontrolled Keywords: Stomach Digestion;Bioaccessability of Food; Stomach Model; Food Particle Breakdown
Subjects: 600 Technology > 01 Medical sciences > 13 Nutrition-Human
Divisions: Food Engineering
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 03 Nov 2016 11:08
Last Modified: 03 Nov 2016 11:08
URI: http://ir.cftri.com/id/eprint/12381

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