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µ-Oxamido binuclear copper (II) complexes: Synthesis, crystal structure, DNA interaction and antibacterial studies

Chetana, P. R. and Ramakrishna, Rao and Debojyoti, Lahiri and Policegoudra, R. S. and Ravish, Sankolli and Aradhya, S. M. (2014) µ-Oxamido binuclear copper (II) complexes: Synthesis, crystal structure, DNA interaction and antibacterial studies. Polyhedron, 68. pp. 172-179.

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Abstract

Four binuclear copper (II) complexes [Cu(oxpn)Cu(B)]2+ (2–5) bridged by N, N0-bis[3-(methylamino) propyl] oxamide (oxpn), where, B is N, N-donor heterocyclic bases (viz. 2,20-bipyridine (bpy, 2), 1,10- phenathroline (phen, 3), dipyrido[3,2-d:20,30-f]quinoxaline (dpq, 4) and dipyrido[3,2-a:20,30-c]phenazine (dppz, 5) are synthesized, characterized by different spectroscopic and single crystal X-ray data technique. The phen (3) and dpq (4) complexes were structurally characterized by X-ray data analysis. Their DNA binding, oxidative cleavage and antibactirial activities were studied. The dpq (4) and dppz (5) complexes are avid binders to the Calf thymus DNA (CT-DNA). The phen (3), dpq (4) and dppz (5) complexes show efficient oxidative cleavage of supercoiled DNA (SC DNA) through hydroxyl radical (�OH) pathway in the presence of Mercaptopropionic acid (MPA).

Item Type: Article
Uncontrolled Keywords: Binuclear Copper (II) Oxpn DNA interaction Antibacterial
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 24 Organic Chemistry
Divisions: Fruit and Vegetable Technology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 27 Sep 2016 08:27
Last Modified: 27 Sep 2016 08:27
URI: http://ir.cftri.com/id/eprint/12370

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