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Antioxidant Properties of Fungal Metabolite Nigerloxin in vitro

Suresha, B. S. and Srinivasan, K. (2013) Antioxidant Properties of Fungal Metabolite Nigerloxin in vitro. Applied Biochemistry and Microbiology, 49 (6). pp. 587-591.

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Abstract—We have recently reported the beneficial influence of the fungal metabolite nigerloxin, a new aldose reductase inhibitor and a lipoxygenase inhibitor on oxidative stress in streptozotocin induced diabetic rats. In the present study we have investigated the antioxidant potential of nigerloxin in vitro as compared to one of the well known natural antioxidant, curcumin. The fungal metabolite nigerloxin was found to be an effective antioxidant in different in vitro assays including the phosphomolybdenum, 2,2�diphenyl�1�picryl� hydrazyl (DPPH•), 2,2'�azino�bis(3�ethylbenzothiazoline�6�sulphonic acid) (ABTS•+) and ferric reducing antioxidant power (FRAP) methods. The antioxidant potency of nigerloxin may be attributed to its electron donating nature. The ferric reducing potency of nigerloxin as demonstrated by FRAP assay method was even found to be superior to that of the natural antioxidant curcumin.

Item Type: Article
Uncontrolled Keywords: fungal metabolite, nigerloxin, antioxidants
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 04 Fungi
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 26 Sep 2016 11:18
Last Modified: 26 Sep 2016 11:18
URI: http://ir.cftri.com/id/eprint/12357

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