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A Short-Term Toxicity Study of Aspergillus Carbonarius Carotenoid

Anbarasu, K. and Akshatha, H.S. and Muthukumar, S. P. and Umesh Kumar, S. (2012) A Short-Term Toxicity Study of Aspergillus Carbonarius Carotenoid. International Journal of Toxicology, 31 (2). pp. 158-165.

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In a pharmacokinetic study, high-performance liquid chromatography analysis of blood samples of Wistar female rats fed with partially saturated canthaxanthin (PSC) of Aspergillus carbonarius showed the presence of the carotenoid in the plasma within 6 hours of feeding. In another study for safety assessment of PSC fed to rats over a period of 28 days at 0.05%, 0.10%, and 0.25%, the rats showed no changes in food intake. There were no significant differences observed in body weight, hematological parameters, or serum clinical enzymes compared to the control group not fed with PSC. Deposition of PSC in the eyes of the rats was also not observed. The results showed that PSC-fed rats were not adversely affected as far as toxicological studies were concerned.

Item Type: Article
Uncontrolled Keywords: Aspergillus, canthaxanthin, safety, Wistar rats, in vivo
Subjects: 500 Natural Sciences and Mathematics > 08 Botanical sciences > 01 Botany > 03 Fungi
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Dept. of Biochemistry
Food Microbiology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 22 Sep 2016 08:22
Last Modified: 22 Sep 2016 08:22
URI: http://ir.cftri.com/id/eprint/12299

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