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Renal lesions in streptozotocin-induced diabetic rats maintained on onion and capsaicin containing diets

Suresh Babu, Poda and Srinivasan, Krishnapura (1999) Renal lesions in streptozotocin-induced diabetic rats maintained on onion and capsaicin containing diets. Journal of Nutritional Biochemistry, 10. pp. 477-583.

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Abstract

Onion (Allium cepa) powder and capsaicin, the pungent principle of red pepper (Capsicum annum) were added in the amounts of 3 g% and 15 mg%, respectively, to the diet of streptozotocin-induced diabetic Wistar rats for 8 weeks. The presence of renal lesions was assessed by the extent and quality of proteinuria and by the leaching of renal tubular enzymes into the urine. Renal integrity was assessed by measuring the activities in the kidney tissue of several key enzymes of carbohydrate metabolism and of polyol pathway, transaminases, and ATPases. Data on enzymuria and proteinuria, activities of kidney ATPases present in diabetic patients, suggested that dietary onion caused significant beneficial modulation of the progression of renal lesions in the diabetic rats. These findings were also corroborated by histologic examination of kidney sections. Dietary capsaicin did not have any favorable influence on renal pathology in diabetes. It is inferred that this beneficial ameliorating influence of dietary onion on diabetic nephropathy may be mediated through onion’s ability to lower blood cholesterol levels and to reduce lipid peroxidation.

Item Type: Article
Uncontrolled Keywords: diabetes mellitus; renal lesions; onion; capsaicin
Subjects: 600 Technology > 08 Food technology > 23 Vegetables > 05 Onion
600 Technology > 01 Medical sciences > 13 Nutrition-Human
600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 22 Jun 2007 04:12
Last Modified: 28 Dec 2011 09:28
URI: http://ir.cftri.com/id/eprint/1224

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