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Modified pectic polysaccharide from turmeric (Curcuma longa):A potent dietary component against gastric ulcer

Harsha, M. R and Serkad, V. and Chandra, Prakash and Shylaja, M. Dharmesh (2016) Modified pectic polysaccharide from turmeric (Curcuma longa):A potent dietary component against gastric ulcer. Carbohydrate Polymers, 138. pp. 143-155.

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Abstract

tNative, intact (TrPP) and modified, low-molecular-weight (MTrPP) forms of pectic polysaccharides iso-lated from turmeric were evaluated for ulcer-preventive potentials in in vitro and in vivo models. Dataindicated that MTrPP possessed significantly better ulcer-preventive property than TrPP; inhibitingulcer scores up to 85%. Results were substantiated by effective muco-protection, H+,K+-ATPase down-regulation, inhibition of H. pylori growth/adherence, higher antioxidant/cytoprotective mechanisms.Structural data indicated TrPP and MTrPP differ in their molecular weights and structural characteristicswith different sugar compositions and side chain ratios. MTrPP was rich in galacturonic acid (687 mg/g;TrPP—544 mg/g) and galactose (52.9%; TrPP—21.7%). Results were substantiated by NMR/FTIR data indi-cating the presence of homogalacturonan and rhamnogalacturonam-I containing galactans. By virtue ofbinding to inflammatory marker (galectin-3), galactans may reduce inflammation induced ulcerations.The low molecular weight of MTrPP (155 kDa; TrPP—13 kDa) may increase its bioavailability than TrPP,thus MTrPP may possess higher antiulcer potential.

Item Type: Article
Uncontrolled Keywords: Dietary/natural Antiulcer Turmeric Modified pectin Galactan
Subjects: 600 Technology > 08 Food technology > 18 Processed foods > 01 Dietary Fiber
600 Technology > 08 Food technology > 30 Spices/Condiments > 07 Turmeric
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 24 Feb 2016 08:16
Last Modified: 24 Feb 2016 08:16
URI: http://ir.cftri.com/id/eprint/12134

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