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Antihyperglycemic, Antioxidant and Antimicrobial Activities of the Butanol Extract from Spirulina Platensis.

Mallikarjun Gouda, K. G. and Kavitha, M. D. and Sarada, R. (2015) Antihyperglycemic, Antioxidant and Antimicrobial Activities of the Butanol Extract from Spirulina Platensis. Journal of Food Biochemistry, 39 (5). pp. 594-602.

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Abstract

The butanol extract of Spirulina was found to have potent α-glucosidase inhibitory activity with an IC50 value of 23.0 ± 0.4 μg/mL. Total phenolic and flavonoid contents were estimated to be 121.0 ± 3.5 mg gallic acid equivalent/100 g and 27.4 ± 1.2 mg rutin equivalent/100 g of Spirulina biomass. The butanol extract also exhibited rat intestinal α-glucosidase inhibitory activity with IC50 value of 37.5 ± 2.8 μg/mL. The butanol extract had showed antioxidant activities with DPPH (1, 1-diphenyl-1-picrylhydrazyl radical), reducing power, hydroxyl radical and nitric oxide scavenging activity and showed antimicrobial activity against gram-positive and gram-negative bacteria. The present results indicate that Spirulina can be used for nutraceutical applications. PRACTICAL APPLICATION Spirulina has Generally Recognized as Safe (GRAS) status and FDA approval for dietary supplement; therefore, it can be used as food supplement for health benefits. The therapeutic approach for preventing diabetes mellitus is to retard the absorption of glucose through inhibition of α-glucosidase.

Item Type: Article
Uncontrolled Keywords: Spirulina, Diabetes mellitus, butanol extract, antioxidant activities
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 01 Algae
600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
Divisions: Plant Cell Biotechnology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 11 Dec 2015 05:40
Last Modified: 11 Dec 2015 05:40
URI: http://ir.cftri.com/id/eprint/12016

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