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Anti-diabetic effect of dietary mango (Mangifera indica L.) peel in streptozotocin-induced diabetic rats.

Mahendranath, Gondi and Shaik Akbar, Basha and Jamuna, J. Bhaskar and Salimath, P. V. and Prasada Rao, U. J. S. (2015) Anti-diabetic effect of dietary mango (Mangifera indica L.) peel in streptozotocin-induced diabetic rats. Journal of the Science of Food and Agriculture, 95 (5). pp. 991-999.

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BACKGROUND: In the present study, the composition of mango peel powder (MPP) collected fromthe mango pulp industrywas determined and the effect ofMPP on ameliorating diabetes and its associated complications was studied. RESULTS: Mango peel was rich in polyphenols, carotenoids and dietary fibre. Peel extract contained various bioactive compounds and was found to be rich in soluble dietary fibre. Peel extract exhibited antioxidant properties and protected against DNA damage. Therefore, the effect of peel on ameliorating diabetes was investigated in a rat model of diabetes. A significant increase in urine sugar, urine volume, fasting blood glucose, total cholesterol, triglycerides and low density lipoprotein, and decrease in high density lipoprotein were observed in the rats; however, these parameters were ameliorated in diabetic rats fed with diet supplemented withmango peel at 5% and 10% levels in basal diet. Treatment of diabetic rats with MPP increased antioxidant enzyme activities and decreased lipid peroxidation in plasma, kidney and liver compared to untreated diabetic rats. Glomerular filtration rate and microalbuminuria levels were ameliorated inMPP treated diabetic group. CONCLUSIONS: Mango peel, a by-product, can be used as an ingredient in functional and therapeutic foods.

Item Type: Article
Uncontrolled Keywords: diabetes; mango peel; antioxidant enzymes; streptozotocin induced diabetes; oxidative stress
Subjects: 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
600 Technology > 08 Food technology > 24 Fruits > 06 Mango
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 30 Nov 2015 12:38
Last Modified: 30 Nov 2015 12:38
URI: http://ir.cftri.com/id/eprint/12011

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