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Dietary fatty acid determines the intestinal absorption of lutein in lutein deficient mice.

Nidhi, Bhatiwada and Ramaprasad, T. R. and Baskaran, V. (2014) Dietary fatty acid determines the intestinal absorption of lutein in lutein deficient mice. Food Research International, 64. pp. 256-263.

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Abstract

The present investigation was undertaken to study the influence of dietary lipids [olive (OO), coconut (CNO), groundnut (GNO), soybean (SBO), sunflower (SFO), rice bran (RBO), corn (CO), palm (PO), fish (FO) oils] on the bioavailability and antioxidant property of lutein in lutein deficient (LD)mice. Lutein (200 μM) was dispersed in dietary lipids and administered to LD mice for a period of 15 days. The plasma lutein levels were found to be highest in OO (82%) and CNO (68%), when compared to the control (mixed micelle) group. Further, positive correlation was found between intestinal triacylglycerol lipase and plasma lutein levels, confirming the crucial role of intestinal lipase on lutein micellarization and its intestinal uptake. Results revealed an affirmative correlation between triglycerides, lowdensity lipoproteins and high density lipoprotein levelswith plasma and tissue lutein levels, signifying their role in the transportation of newly absorbed lutein to target tissues. Furthermore, lutein accumulation in the liver and the eye was highest in the OO (120% and 117%) and CNO (105% and 109%) fed groups, compared to control. Lutein deficiency resulted in elevated (p b 0.05) levels of lipid peroxides, superoxide dismutase, and catalase in plasma and liver microsomes, which have been decreased significantly on feeding lutein. These resultsmay be due to the influence of oleic (dominant in OO) and lauric (dominant in CNO) acids on the activity of intestinal lipase, portal absorption, triglycerides, lipoprotein or cholesterol flux between liver and peripheral tissues, which may modulate the uptake and transport of lutein.

Item Type: Article
Uncontrolled Keywords: Bioavailability Coconut oil Lutein Lutein deficiency Olive oil Triacylglycerol lipases
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 17 Fatty Acid Chemistry
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 16 Oct 2014 09:23
Last Modified: 16 Oct 2014 09:23
URI: http://ir.cftri.com/id/eprint/11656

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