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Olive oil improves the intestinal absorption and bioavailability of lutein in lutein-deficient mice.

Nidhi, Bhatiwada and Mamatha, B. S. and Baskaran, V. (2014) Olive oil improves the intestinal absorption and bioavailability of lutein in lutein-deficient mice. European Journal of Nutrition, 53. pp. 117-126.

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Abstract

To investigate the influence of olive (OO), groundnut (GNO), soybean (SBO), sunflower (SFO), rice bran (RBO), corn (CO), palm (PO) oil or mixed micelle (control) on absorption kinetics and bioavailability of lutein in lutein-deficient mice. Additional aim was to correlate the activity of intestinal triacylglycerol lipase with intestinal and plasma lutein levels. Methods After induction of lutein deficiency, mice (n = 165) were divided into eight groups (OO, SFO, GNO, RBO, PO, CO, SBO and control; n = 20/group) and the remaining (n = 5) were used as baseline (0 h). Groups were further divided into four subgroups (n = 5/subgroup) and were intubated with lutein (200 lM) dispersed in different vegetable oils. Plasma and tissue (intestine, liver and eyes), lutein, triglycerides, intestinal triacylglycerol lipases and fatty acid profile of plasma and tissues were measured at different time intervals. Results The percentage area under the curve value for plasma lutein in OO and GNO was higher by 41.8 and 5.1 %, while it was lower in other groups (18.2–53.3 %), when compared to control. Similarly, the percentage area under the curve for eye lutein in OO and GNO groups was higher by 35.2 and 4.8 %, whereas in other groups it was lower (5.4–69 %) than in control. Results show that olive oil facilitates the lutein absorption more compared to other vegetable oils, which may be due to the difference in fatty acid composition and higher activity of intestinal triacylglycerol lipase. Conclusions Dietary olive oil rich in oleic acid improves the bioavailability and accumulation of lutein in luteindeficient mice by modifying the intestinal triacylglycerol lipase activity.

Item Type: Article
Uncontrolled Keywords: Absorption kinetics Bioavailability Lutein deficiency Triacylglycerol lipase Vegetable oils
Subjects: 600 Technology > 08 Food technology > 19 Lipids-oils/fats > 01 Oilseeds
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 25 Apr 2014 11:14
Last Modified: 25 Apr 2014 11:14
URI: http://ir.cftri.com/id/eprint/11471

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