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In vivo bioavailability and antioxidant activity of carotenoids from microalgal biomass — A repeated dose study.

Ranga Rao, A. and Baskaran, V. and Sarada, R. and Ravishankar, G. A. (2013) In vivo bioavailability and antioxidant activity of carotenoids from microalgal biomass — A repeated dose study. Food Research International, 54. pp. 711-717.

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Abstract

The present study is focused on bioavailability and antioxidant property of carotenoids from microalgal biomass elucidated in rat model. Microalgal biomass containing 200 μMequivalent of β-carotene, astaxanthin and lutein per rat from Spirulina platensis, Haematococcus pluvialis and Botryococcus braunii biomass respectively was dispersed in olive oil and administered to rats for a period of 15 days. The levels of these carotenoids in the plasma, liver and eye were examined by high performance liquid chromatography and also confirmed by mass spectroscopy. The maximum peak levels (nmol/g) of β-carotene (615.61 ± 85.54), astaxanthin (896.51 ± 101.76) and lutein (679.55 ± 74.08) were detected in the liver followed by the eye and plasma. Astaxanthin accumulation in rats fed with H. pluvialis group was higher when compared to S. platensis and B. braunii groups. In H. pluvialis fed group, antioxidant enzymes catalase, superoxide dismutase, peroxidase and lipid peroxidation levels were high in the plasma and liver compared to S. platensis and B. braunii fed groups. These results indicate that the astaxanthin from H. pluvialis has better bioavailability and better antioxidant properties compared to other carotenoids.

Item Type: Article
Uncontrolled Keywords: Microalgae, Carotenoids, Bioavailability, Antioxidant property, HPLC LC–MS
Subjects: 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 01 Algae
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Dept. of Biochemistry
Plant Cell Biotechnology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 23 Sep 2013 07:09
Last Modified: 03 Jul 2015 07:39
URI: http://ir.cftri.com/id/eprint/11263

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