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Oxidative DNA cleavage, cytotoxicity and antimicrobial studies of L-ornithine copper (II) complexes.

Chetana, P. R. and Ramakrishna, Rao and Sounik, Saha and Policegoudra, R. S. (2012) Oxidative DNA cleavage, cytotoxicity and antimicrobial studies of L-ornithine copper (II) complexes. Polyhedron, 48. pp. 43-50.

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Abstract

New ternary copper (II) complexes, [Cu(L-orn)(B)(Cl)](Cl�2H2O) (1–2) where L-orn is L-ornithine, B is an N,N-donor heterocyclic base, viz. 2,20-bipyridine (bpy, 1) and 1,10-phenanthroline (phen, 2), were synthesized and characterized by various spectroscopic techniques. Complex 2 is characterized by the X-ray single crystallographic method. The complex shows a distorted square-pyramidal (4 + 1) CuN3OCl coordination sphere. Binding interactions of the complexes with calf thymus DNA (CT-DNA) were investigated by UV–Vis absorption titration, ethidium bromide displacement assay, viscometric titration experiment and DNA melting studies. Complex 2 shows appreciable chemical nuclease activity in the presence of 3-mercaptopropionic acid (MPA). The complexes were subjected to in vitro cytotoxicity studies against carcinomic human alveolar basal epithelial cells (A-549) and human epithelial (HEp-2) cells. The IC50 values of 1 and 2 are less than that of cisplatin against HEp-2 cell lines. MIC values for 1 against the bacterial strains Streptococcus mutans and Pseudomonas aeruginosa are 0.5 mM.

Item Type: Article
Uncontrolled Keywords: Ornithine, Copper (II), DNA cleavage A-549, HEp-2 Antibacterial activity
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 24 Organic Chemistry
Divisions: Fruit and Vegetable Technology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 08 Mar 2013 06:20
Last Modified: 01 Jul 2015 10:47
URI: http://ir.cftri.com/id/eprint/11125

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