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Ocimum sanctum and Morus alba Leaves and Punica granatum Seeds in Diet Ameliorate Diabetes-Induced Changes in Kidney.

Abignan Gurukar, M. S. and Nandini, Chilkunda D. and Mahadevamma, S. and Salimath, P. V. (2012) Ocimum sanctum and Morus alba Leaves and Punica granatum Seeds in Diet Ameliorate Diabetes-Induced Changes in Kidney. Journal of Pharmacy Research, 5 (9). pp. 4729-4733.

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Abstract

The effect of Ocimum sanctum (Tulsi) leaves, Morus alba L. (mulberry) leaves and Punica granatum (Pomegranate) seeds were evaluated for diabetesmediated effect on kidney of streptozotocin-induced diabetic rats. Rats (both control and diabetic) were fed with tulsi leaves, mulberry leaves and pomegranate seeds individually at 10%, 10% and 7.5 %, respectively, in AIN-76 diet, for a period of two months. Dietary supplements in the diet were able to ameliorate the increase in various parameters such as blood glucose, albumin excretion, glomerular filtration rate and kidney index. All the abovementioned dietary supplements had positive influence on extracellular matrix components such as laminin and fibronectin of kidney to various extents. The results indicated that plant materials of dietary origin are able to circumvent diabetes-induced changes in extracellular matrix components there by bringing about beneficial effects in the kidney.

Item Type: Article
Uncontrolled Keywords: Diabetes, Kidney, Extracellular matrix, Tulsi leaves, Mulberry leaves, and Pomegranate seeds
Subjects: 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
600 Technology > 03 Agriculture > 04 Medicinal Plants
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 06 Dec 2012 06:11
Last Modified: 21 Dec 2016 13:15
URI: http://ir.cftri.com/id/eprint/11067

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