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Effect of curcumin and quercetin on lysosomal enzyme activities in streptozotocin-induced diabetic rats.

Mallikarjun, B. Chougala and Jamuna, J. Bhaskar and Rajan, M. G. R. and Salimath, P. V. (2012) Effect of curcumin and quercetin on lysosomal enzyme activities in streptozotocin-induced diabetic rats. Clinical Nutrition, 31. pp. 749-755.

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Background & aims: Diabetes causes impairment of various enzyme activities in the physiological system, including lysosomal enzymes. The effect of feeding curcumin, quercetin and aminoguanidine on lysosomal enzyme activities viz., N-acetyl-b-D-glucosaminidase, b-D-glucuronidase, b-D-galactosidase and acid phosphatase were studied in different tissues of streptozotocin-induced diabetic rats. Method: Rats were divided into four control groups and four diabetic groups. Experimental groups were fed with diet supplemented with curcumin (0.5%) or quercetin (0.1%) or aminoguanidine (0.05%). Lysosomal enzyme activities were determined in various tissues. Results: The specific activity of N-acetyl-b-D-glucosaminidase in liver of diabetic rats was decreased when compared to control rats and was ameliorated with curcumin and quercetin treatment by 67% and 78%, respectively. On the other hand, b-D-glucuronidase activity was higher in the brain of diabetic rats (0.90 � 0.04 nmol/mg protein/min), when compared to control rats (0.45 � 0.02 nmol/mg protein/min) and was decreased in curcumin (0.75 � 0.05 nmol/mg protein/min) and quercetin (0.74 � 0.11 nmol/mg protein/min) treated rats. b-D-galactosidase activity in spleen of curcumin and quercetin fed diabetic group rats was ameliorated by 68% and 58%, respectively, in comparison to diabetic rats. Acid phosphatase activity in diabetic rats decreased in testis when compared to control. Conclusion: Curcumin and quercetin feeding modulated lysosomal enzyme activities in different tissues during diabetes and the effect was comparable to well-known anti-glycative agent - aminoguanidine.

Item Type: Article
Uncontrolled Keywords: Diabetes, Glycoconjugates, Lysosomal enzymes Curcumin, Quercetin Aminoguanidine
Subjects: 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
600 Technology > 08 Food technology > 16 Nutritive value > 05 Enzymes
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 06 Nov 2012 10:54
Last Modified: 30 Dec 2016 08:38
URI: http://ir.cftri.com/id/eprint/10989

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