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Differential cholinesterase inhibition in the rat brain regions by dichlorvos and protective effect of Decalepis hamiltonii roots

Anup, Srivastava and Shivanandappa, T. (2011) Differential cholinesterase inhibition in the rat brain regions by dichlorvos and protective effect of Decalepis hamiltonii roots. NeuroToxicology, 32 (6). pp. 931-934.

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Abstract

Dichlorvos (DDVP) causes neurotoxicity primarily by inhibiting cholinesterase (ChE) which is the characteristic feature of organophosphate pesticides. In this study, we found for the first time that DDVP shows differential inhibition of ChE (acetylcholinesterase + butyrylcholinesterase) in various rat brain regions. A single dose of DDVP (1/3 LD50) after 16 h of treatment elicited ChE inhibition in the brain regions which was highest in striatum and lowest in cerebellum. The inhibition of ChE by DDVP has been shown to be accompanied with induction of oxidative stress. Further, we investigated the protective potential of the aqueous extract of the roots of Decalepis hamiltonii (DHA), having potent antioxidant constituents, against DDVP-induced ChE inhibition in various rat brain regions. Pretreatment of rats with multiple doses of DHA, 50 and 100 mg/kg b.w., for 7 consecutive days did not produce any significant change in ChE activity. Pretreatment of rats with DHA, at high dose, significantly protected against DDVP-induced ChE inhibition in all the brain regions except cerebellum. Pretreatment of rats with DHA, at low dose, showed significant protection in striatum, cortex, and pons against DDVP-induced ChE inhibition. The protective activity of DHA can be attributed to the characterized potent antioxidant constituents which could have an important role in preventing ChE inhibition by inducing the DDVP detoxifying enzymes. We strongly believe that these antioxidant constituents are prospective novel nutriceuticals.

Item Type: Article
Uncontrolled Keywords: Dichlorvos (DDVP); Cholinesterase; Brain regions; Decalepis hamiltonii
Subjects: 500 Natural Sciences and Mathematics > 10 Plants > 06 Trees And Shrubs
600 Technology > 01 Medical sciences > 17 Toxicology
Divisions: Food Protectants and Infestation Control
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 04 Dec 2017 08:52
Last Modified: 04 Dec 2017 08:52
URI: http://ir.cftri.com/id/eprint/10800

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