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Safety evaluation of Mucor rouxii CFR-G15 biomass containing ω-6 fatty acids in rats

Mamatha, S. S. and Muthukumar, S. P. and Venkateswaran, G. (2012) Safety evaluation of Mucor rouxii CFR-G15 biomass containing ω-6 fatty acids in rats. Regulatory Toxicology and Pharmacology, 62 (1). pp. 183-190.

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Abstract

Mucor rouxii CFR-G15 is an oleaginous zygomycetous fungus. The mycelia of the fungus accumulate 35.0 ± 0.8% total lipid of which, 18.55 ± 0.46% is gamma linolenic acid. Acute and subchronic studies were conducted by feeding rats with dry biomass of M. rouxii CFR-G15 to assess the safety of the oils in the fungal mycelium. For acute toxicity studies, adult male rats fed with diet at 0, 5000, 10,000, 25,000, 50,000 mg/kg bw for 1 day, and the animals were monitored for 14 days. Rats weighing 35 ± 2.5 g were fed for 13 weeks with a diet incorporating 2500, 5000, 10,000 and 20,000 mg/kg (w/w) dry biomass for subchronic toxicity studies. Control consists of the diet without the dry biomass. Dietary feeding of M. rouxii biomass at any level showed no significant changes (p > 0.05) in food intake, body weight, organs weight and serum enzymes. Macroscopic and microscopic observations revealed that the vital organs were unaffected by the feed containing the dry biomass. However, triglycerides and cholesterol levels in serum were decreased significantly (p < 0.05) in the test rats. The results of this study suggests that feeding fungal mycelia containing oil is safe when fed to rats and also shows positive effects on controlling triglycerides and cholesterol.

Item Type: Article
Uncontrolled Keywords: Mucor rouxii; Biomass; Polyunsaturated fatty acids; Experimental animals; Gamma linolenic acid; Safety; Serum; Toxicity; Sub-chronic
Subjects: 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 17 Fatty Acid Chemistry
500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 04 Fungi
Divisions: Dept. of Biochemistry
Food Microbiology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 03 Oct 2016 05:51
Last Modified: 03 Oct 2016 05:51
URI: http://ir.cftri.com/id/eprint/10797

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