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New scalable and eco-friendly synthesis of gingerols

Vijendra Kumar, N. and Srinivas, P. and Bettadaiah, B. K. (2012) New scalable and eco-friendly synthesis of gingerols. Tetrahedron Letters, 53. pp. 2993-2995. ISSN 0040-4039

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Abstract

Synthesis of 6-gingerol and its congeners 7- and 9-gingerols has been achieved from eugenol by a new scalable and eco-friendly protocol. The key steps are functionalization of eugenol to the nitro compound and its reaction under optimized condition with terminal alkenes to afford intermediate isoxazolines. The latter on catalytic hydrogenation in presence of Raney nickel afford corresponding gingerols in good yields.

Item Type: Article
Uncontrolled Keywords: 6-Gingerol, Eugenol, Hydroboration, Eugenyl iodide Isoxazolines, Olefins, Reduction
Subjects: 600 Technology > 08 Food technology > 01 Analysis
600 Technology > 08 Food technology > 30 Spices/Condiments
Divisions: Plantation Products Spices and Flavour Technology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 22 May 2012 04:06
Last Modified: 28 Aug 2018 05:51
URI: http://ir.cftri.com/id/eprint/10776

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