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A novel cytoprotective antioxidant: 4-Hydroxyisophthalic acid.

Anup, Srivastava and Jagan Mohan Rao, L. and Shivanandappa, T. (2012) A novel cytoprotective antioxidant: 4-Hydroxyisophthalic acid. Food Chemistry, 132. pp. 1959-1965. ISSN 0308-8146

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The antioxidant and cytoprotective properties of 4-hydroxyisophthalic acid (4-HIPA) isolated from the Decalepis hamiltonii roots was examined. 4-HIPA is a potent scavenger of superoxide (O2 ��), hydroxyl (�OH), nitric oxide (�NO), and lipid peroxide (LOO�) physiologically relevant free radicals with IC50 values in the nanomolar (2–187) range. 4-HIPA also exhibits a concentration dependent secondary antioxidant activities like reducing power, metal chelating activity, and inhibition of protein carbonylation. Further, 4-HIPA at nanomolar concentration prevented CuSO4-induced human LDL oxidation. 4-HIPA demonstrated cytoprotective activity in primary hepatocytes and Ehrlich Ascites tumour (EAT) cells against oxidative stress inducing xenobiotics apart from the in vitro free radical scavenging activity. The mechanism of cytoprotective action involved maintaining the intracellular glutathione (GSH), scavenging of reactive oxygen species (ROS), and inhibition of lipid peroxidation (LPO). Thus, 4-HIPA is a novel bioactive molecule with potential health implications.

Item Type: Article
Uncontrolled Keywords: 4-Hydroxyisophthalic acid, Decalepis hamiltonii Antioxidant, ROS, Lipid peroxidation, Glutathione
Subjects: 500 Natural Sciences and Mathematics > 10 Plants
600 Technology > 08 Food technology > 32 Antioxidants
Divisions: Food Protectants and Infestation Control
Plantation Products Spices and Flavour Technology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 23 Feb 2012 05:57
Last Modified: 24 Sep 2018 08:39
URI: http://ir.cftri.com/id/eprint/10656

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