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Inclusion of Ring A of Cholesterol Inside the β-Cyclodextrin Cavity: Evidence from Oxidation Reactions and Structural Studies.

Ramaswamy, R. and Divakar, S. (1998) Inclusion of Ring A of Cholesterol Inside the β-Cyclodextrin Cavity: Evidence from Oxidation Reactions and Structural Studies. Journal of Inclusion Phenomena and Molecular Recognition in Chemistry , 30. 253-270.

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Abstract

The disposition of cholesterol inside the �cyclodextrin cavity (�CD) was deduced from oxidation of cholesterol secondary alcohol groups by Ca(OCl)2 and H2O2 in the pyridine–acetic acid system. The amount of cholest4ene3one formed was found to be proportional to the concentration of �cyclodextrin, resulting in 56.1% of ketone. The oxidation rate was enhanced by �cyclodextrin and its methyl, polymer and 1 : 1 copper(II)–�cyclodextrin derivatives. Detailed investigations involving UVvisible, 13Cand 1HNMR (T1, 1D NOE and ROESY) spectroscopic studies were carried out. A binding constant value of 15,385 � 1500 M

Item Type: Article
Uncontrolled Keywords: Beta-CD cholesterol, DMBeta-CD cholesterol, intermolecular NOE.
Subjects: 600 Technology > 08 Food technology > 09 Food Microbiology
Divisions: Food Microbiology
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 20 Feb 2012 09:19
Last Modified: 30 Dec 2016 11:05
URI: http://ir.cftri.com/id/eprint/10644

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